Report of SRI activities and Impact for the year November 2023 to November 2024
Executive Summary
q Our reviews have contributed to 32 international and national guidelines and the Transfusion Evidence Library has been referenced in at least 17 published papers.
q One new research grant applications have been made using evidence taken from one of our systematic reviews [see details on page 17].
q Three complex systematic reviews were completed and published [see citations detailed on page 2].
q A further five full systematic reviews
are going through peer review [see details on page 3].
q We have continued our collaboration with ISBT, including recording the first in a new podcast series “Talking Transfusion” which discussed October 2024’s Transfusion Evidence Round-Up focussing on ‘World Trauma Day’ [see details on page 4].
q We have
been working with an external collaborator, Mixd, to build a website for the
SRI.
q We have increased the variety of our engagement activities this year [see details on page 4 to 7].
q We have continued to grow our Twitter/X [@TransfusionLib, @sritransfusion and @stemcell] and LinkedIn accounts to engage with our library communities and increase our dissemination activities.
How does this year’s output and impact
compare to last year?
· We have published less reviews [three
compared to 11] and have five reviews going through peer review [three last
year].
· We have found more evidence of the
citing of our reviews in new guidelines [32 guidelines compared to 20 last
year] with more of our reviews cited [ 32 reviews compared to 18 last year].
· The Transfusion Evidence Library has
been referenced in fewer journal publications [17 compared to 26].
· The number of followers for each
Twitter/X account has increased – by 5% for Transfusion Evidence Library, 19%
for the SRI and 6% for Stem Cell Evidence: slightly smaller increases compared
to those seen between November 2022 and October 2023.
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Section |
Our Evidence |
|
Publications since November 2023 Explanations of Complexity
descriptors A simple review includes only RCTs and includes <10 RCTs. A medium review includes only RCTs and includes between 10 and 100 RCTs. Or a review of mixed study types with no risk of bias and statistical analysis. A complex review is any of the following includes
non-randomised studies; uses methodology such as IPD or NMA; includes more
than 100 studies or is a significant update of an already published
systematic review, for example requires a total rewrite of methods and
therefore extraction and analysis of already included data. |
3 Complex reviews; 1 Protocol; 1
search support; 1 statistical support Cain L, Geneen LJ, Wiltshire M, Kimber C, Proffitt S, Sandercock J, Dorée C, Brunskill SJ, Estcourt LJ. Universal irradiation of platelets: Does irradiation affect the quality, effectiveness, and safety of platelets for transfusion? Transfus Med Rev. 2024 Jul 4:150840. doi: 10.1016/j.tmrv.2024.150840. Epub ahead of print. PMID: 39019680 [N = 44] Chai KL, Wood EM, Estcourt LJ, Csenar M, Iannizzi C, Monsef I, Macphail A, Carrillo de Alboronz S, McQuilten Z. Immunoglobulin replacement to prevent infections in people with haematological malignancies and haematopoietic stem cell transplantation. Cochrane Database of Systematic Reviews 2024, Issue 3. Art. No.: CD015719. DOI: 10.1002/14651858.CD015719. PROTOCOL Gibbs VN, Champaneria R, Sandercock J, Welton NJ, Geneen LJ, Brunskill SJ, Dorée C, Kimber C, Palmer AJ, Estcourt LJ. Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee surgery: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2024 Jan 16;1(1):CD013295. doi: 10.1002/14651858.CD013295.pub2. PMID: 38226724; PMCID: PMC10790339 [N = 102] Peck RC, Knapp-Wilson A, Burley K, Dorée C, Griffin J, Mumford AD, Stanworth S, Sharplin K. Scoping Review of Factors Associated with Stem Cell Mobilization and Collection in Allogeneic Stem Cell Donors. Transplant Cell Ther. 2024 Sep;30(9):844-863. doi: 10.1016/j.jtct.2024.06.002. Epub 2024 Jun 6. PMID: 38851322. Search only Radford M, Estcourt LJ, Sirotich E, Pitre T, Britto J, Watson M, Brunskill SJ, Fergusson DA, Dorée C, Arnold DM. Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support. Cochrane Database Syst Rev. 2024 May 23;5(5):CD011305. doi: 10.1002/14651858.CD011305.pub3. PMID: 38780066; PMCID: PMC1111298 [N = 9] Tingle SJ, Kourounis G, Liu F, Wilson CH, Richardson R, Sandercock J. Simple tool implementing Bucher's method for indirect treatment comparisons in meta-analyses. BMJ Evid Based Med. 2024 Jul 30:bmjebm-2024-113103. doi: 10.1136/bmjebm-2024-113103. Epub ahead of print. PMID: 39079909 Statistical Support only Going through peer review: · A systematic review of alloimmunisation in RhD negative patients following the transfusion of RhD positive platelets. [N = 31] · Is there a difference in clinical outcomes between ABO identical compared to ABO non-identical platelets for patients receiving a platelet transfusion? [N = 40] · Pathogen Reduced Platelets for the prevention of bleeding. (Cochrane) [N= 16]. · Red cell transfusion management for patients undergoing cardiac surgery for congenital heart disease. (Cochrane) [N = 20. · Strategies for use of blood products for major bleeding in trauma (Cochrane) – substantial update as new search added during peer review and 6 new studies identified [N = 19] |
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Collaborations with people outside the SRI. These have been grouped by type of project. New collaborators this year are identified by an * at the beginning of their details. |
We
have collaborated with many clinicians and researchers over the last 12
months. Their names and affiliations are provided here: Stem Cell Evidence: Dr
James Griffin – NHSBT, UK. Mr
John Muth - Evidentia
Publishing, UK. Mr
Mark Schregardus – Evidentia
Publishing, The Netherlands. Mr
Michael Studman - Evidentia Publishing, UK. Transfusion Evidence Round-Ups Dr
Gwen Clarke – University of Alberta, Calgary, Canada. Beatriz
Galindo – ISBT Central Office, The Netherlands.
Eszter Herczenik
– ISBT Central Office, The Netherlands.
Dr Victor Lin – The Royal Melbourne Hospital, Australia. Dr Allison Mo - Monash University, Melbourne, Australia.
Marion
Molliet – ISBT Central Office, The Netherlands.
Dr Harriet Tucker – St George’s University Hospital, London, UK Jenny
White – Executive Director, ISBT, The Netherlands. Professor Erica Wood - Transfusion Research Unit, Melbourne, Australia. Systematic review collaborators: Dr Alisha Allana - University Hospital Southampton NHS Foundation Trust, UK. Dr
Cath Booth – Royal Barts NHS Trust, UK. Dr
Lorna Cain – NHSBT, UK. Dr
Rebecca Cardigan - NHSBT, UK. Dr Nikki Curry - Oxford University Hospitals NHS Foundation Trust, UK. *Zareen
Deplano – NHSBT. Paula
Dhiman – University of Oxford, Oxford, UK. Dr Arthur Disegna - University of Oxford, Oxford, UK. Dr
Vishakha Erasu - Oxford
University Hospitals NHS Foundation Trust, UK. A/Prof
Jez Fabes – Peninsula Medical School & Derriford Hospital, Plymouth, UK. Professor Laura Green – NHSBT & Barts Health NHS Trust, UK. Dr Alvin Katumba - Oxford University Hospitals NHS Foundation Trust, UK. *Dr Jade King - NHSBT & Barts Health NHS Trust, UK. *Fiona
Hunt – NHSBT & NHS Lothian, Scotland. *Dr
Lizzie Hutchinson - Oxford University Hospitals NHS Foundation Trust, UK. Dr
Eleni Louka - Great Ormand Street Hospital, London, UK. Mr. Devender Mittapalli - University Hospitals Plymouth NHS Trust, UK. Dr
Allison Mo - Monash University, Melbourne, Australia. Dr Gaurav Nigam - Oxford University Hospitals NHS Foundation Trust, UK Dr Alex Novak - Oxford University Hospitals NHS Foundation Trust, UK Vanessa
Piechotta – Cochrane Haematology, Cologne, Germany. Dr
Matthew Poynton - Oxford University Hospitals NHS Foundation Trust, UK. Sue
Proffitt - NHSBT, UK. A/Professor Noemi Roy - Oxford University Hospitals NHS Foundation Trust, UK *Dr Nikolaos Sousos – University of Oxford, UK. *Dr
Sam Tingle - Professor Nicky Welton – University of Bristol, UK. Dr Kirstin Wilkinson – University Hospital
Southampton NHS Foundation Trust, UK. Dr Mike Wiltshire - NHSBT, UK Professor Erica Wood - Transfusion Research Unit, Melbourne, Australia |
|
Further Funding |
Two funding applications were made between November 2023 and November 2024 1. Lise Estcourt applied to NHSBT small research grants in late 2023 for funds to support the health economic work being planned for out ‘plasma exchanged versus IVIG in neurologic al patients.’ The application for £68,000 was successful. 2. Susan Brunskill applied to NHSBT NIHR Research Capability Funds in May 2024 for the salary costs for the sole member of salaried staff working on the Transplant Library for the financial year March 2024 to March 2025. The application was for £47,000. The application was successful. |
|
Next Destination & Skills |
No
one has left the SRI within the last 12 months. |
|
Engagement Activities |
Transfusion Evidence Round-Up In
2021, we have teamed up with ISBT to produce a quarterly Transfusion Evidence
Round-Up. Four Round-Ups have been published in the last 12 months: · The Best of the Transfusion Evidence Library (18th December 2023) ·
World Kidney Day (14 March 2024) ·
International Children’s Day (12 May 2024) · World Trauma Day (17th October 2024) For
the last 18 months, each Round-Up has been followed up by a live, one hour
webinar, co-chaired by Dr Allison Mo and the SRI team. During these webinars,
each of the three members of the ISBT community who chose the 10 references
for the Round-Up talk through their ‘top’ record of the 10 selected records.
The webinars are hosted by ISBT and are open to anyone within the ISBT
community. The June Round-Up webinar was presented as an invited workshop at
the ISBT annual conference on 25th June 2024, with the collaboration of Susan Brunskill and Catherine Kimber. We have had very positive feedback from all webinars but have decided to explore whether a podcast would be a better accessibility option for an international audience. The first podcast was recorded for the World Trauma Day Round-Up and was released to coincide with the release of the Round-Up. Each
Round-Up is promoted on Twitter/X through the SRI, Transfusion Evidence
Library and ISBT feeds. We have reviewed analytics data following each
Round-Up and take up continues to be similar to that of the monthly evidence
alerts. Social media activity: We
run 3 Twitter/X accounts and 3 LinkedIn accounts: one for each of our
electronic libraries and one for the SRI overall. Our activity on these
accounts is our principal online presence strategy and consists of: ·
Creating and sharing visual infographics for each newly published
systematic review ·
Sharing the PICO summary for each record featured in our monthly
Evidence Alerts and quarterly Round-Ups ·
We also maintain a Facebook account for each of the libraries, although
our primary focus remains Twitter/X. Our Twitter/X accounts have a combined total of 4,719 followers: · 579 [up from 548 in October 2023] for Stem Cell Evidence · 3456 [up from 3303 in October 2023] for Transfusion Evidence Library · 684 [up from 576 in October 2023] for SRI. Visual Infographics are created by Alicia and revies authors for all new publications and made available on our Twitter, LinkedIn, and Facebook accounts. We also post details of the PICO criteria of all papers that appear in a Round-Up top 10 on our relevant Twitter accounts. Talks, Podcasts and Presentations Members of the SRI have given the following talks and workshops over the last year: · Lise Estcourt led a session on ‘Major Haemorrhage’ and two panel discussions, one each on ‘major haemorrhage’ and ‘research’ at the ISBT Highlight Day & 15th Arab Transfusion Medicine Forum, Egypt, [virtual sessions] in January 2024. · Lise Estcourt delivered a presentation on BTRU, Donor Health and Behaviour, ‘The Danish Blood Donor Study’ current research and future possibilities, in Denmark, in January 2024. · Susan Brunskill delivered a talk on What is a systematic review, to the Statistics and Clinical Research Seminar Series, virtual 26th March 2024 · Catherine Kimber managed a stand dedicated to Stem Cell Evidence at the EBMT annual conference, Glasgow, April 2024. · Lise Estcourt delivered a talk on ‘Passive immunotherapy for COVID-19 - focus on Covid Convalescent Plasma and Hyper-IVIG’, at ICTMG/AABB meeting, Washington, US, May 2024. · Susan Brunskill and Catherine Kimber delivered a workshop on “How to review an article: Interactive workshop with the experts” at ISBT annual conference, Barcelona, June 2024. · Lise Estcourt delivered a talk on ‘Risk of ABO incompatible platelets and plasma’ at ISBT annual conference, Barcelona, Spain, June 2024. · Lise Estcourt delivered a talk on ‘Dealing with the risk of incompatible transfusions’ at ISBT annual conference, Barcelona, Spain, June 2024. · Alicia Plaza Cajide managed a stand dedicated to the Transfusion Evidence Library at the SHOT annual symposium, Manchester, 9th July 2024. · Susan Brunskill managed a stand dedicated to the Transfusion Evidence Library at the BBTS annual conference, Glasgow, 16 to 19 September 2024. · Lise Estcourt delivered a talk on ‘National: Transfusion Transformation - Appropriate blood use- ensuring there is blood available for those that need it ‘at the BBTS annual conference, Glasgow, 16 to 19 September 2024. · Josie Sandercock delivered a talk on ‘Challenges extracting data from the literature: what researchers can do to maximise the impact of their research by reporting the details needed for systematic review’, to the Statistics and Clinical Research Seminar Series, virtual 17th October 2024. · Susan Brunskill delivered a talk to second year students on the NHSBT support MSc in Transfusion and Transplantation on ‘The differences between a systematic review and literature review’, virtual 7th October 2024. · Susan Brunskill delivered a talk to first year students on the NHSBT support MSc in Transfusion and Transplantation on ‘Establishing strength of evidence required for research and study designs’, virtual 15th October 2024. · Louise Geneen delivered a talk to first year students on the NHSBT support MSc in Transfusion and Transplantation on ‘Critical Appraisal and Risk of Bias’, virtual 29h October 2024. Presented posters at the following conferences: · Catherine Kimber on Safety and effectiveness of irradiated platelets for transfusion: systematic review and meta-analysis of in-vitro, in-vivo, and clinical outcomes”, 8th International Congress of the ISBT, Barcelona, Spain, June 2024. · Lise Estcourt on Pathogen-reduced platelets for the prevention of bleeding: systematic review and meta-analysis (an update, 8th International Congress of the ISBT, Barcelona, Spain, June 2024. · Susan Brunskill on Statistical analysis of split sample laboratory studies: observations from a systematic review of irradiated platelets, 8th International Congress of the ISBT, Barcelona, Spain, June 2024. · Louise Geneen on Development and use of a new risk of bias (ROB) tool for use in paired sample (in-vitro) laboratory studies, Cochrane/Global Evidence Summit, Prague, September 2024. Recorded the following webinars and podcasts:· Catherine Kimber and Susan Brunskill facilitated the ISBT Live Journal Club Transfusion Evidence Round-Up: Best of the Transfusion Evidence Library December 2023 ·
For Cochrane, Naomi Gibbs
on ‘What is the
best medication to stop bleeding in those having non-emergency hip or knee
surgery? Using data from the Cochrane review Pharmacological interventions
for the prevention of bleeding in people undergoing elective hip or knee
surgery: a systematic review and network meta‐analysis, 7th March
2024. ·
For the Transfusion
Evidence Round-Up focused on World Kidney Day, Catherine
Kimber and Susan Brunskill, facilitated a webinar on the top 3 reviewers’ choices,
March 2024.
·
‘Talking Transfusion
1’, Catherine Kimber and Susan Brunskill, a podcast for the Transfusion Evidence Round-Up which
presented papers relevant to World Trauma Day on 17th October
2024.
Teaching and support activities that the SRI staff provide to Clinical Fellows and other staff through the year. ·
All systematic reviewers within the SRI have provided training on
systematic review processes and methodology for all our completed and ongoing
systematic reviews. Further, we have: · Provided training on how
to use Covidence for screening for all new reviewers [as asterixed
in ‘Systematic Review Collaborators on pages 4 and 5]: all SRI team members. · Provided project
management support and advice to a new Clinical Fellow, Dr Lorna Cain: Louise
Geneen · Provided training on
‘how to do an overview’ to Dr Alwyn Kotze: Lise Estcourt · Co-developed a Risk of
Bias tool for laboratory studies and provided data management support for the
Universal Irradiation systematic review: Louise Geneen, Josie Sandercock,
Catherine Kimber, Lise Estcourt. · Provided support on how
to use RevManWeb to Dr Alwyn Kotze: Lise Estcourt
and Dr Kirstin Wilkinson: Catherine Kimber. · Providing statistical
advice on two research projects being undertaken by people outside NHSBT:
Josie Sandercock. SRI
website. In December 2022, we again explored creating a stand alone SRI website, rather than only having a sub-site of the JPAC transfusion guidelines website (https://www.transfusionguidelines.org/systematic-review-initiative). Following a tender process in late 2023, we contracted in January 2024 with Mixd, “a digital agency committed to the public sector” https://www.mixd.co.uk/. It has been an interesting 10 months since, but we now have a new website that will be live by the end of 2024. Currently the website is going through extensive usability testing and all required policies [cookies, accessibility terms of reference and privacy] are being reviewed by the relevant department within NHSBT. We will be using the same domain name as we have always used, which is www.systematicreviewinitiative.com |
|
Influence on Policy |
We explored
‘influence on policy’ by searching for guidelines in which our reviews have
been cited since the last meeting. From November 2023 to November 2024, 32
international guidelines have been published which have been informed by 35
SRI systematic reviews (57 citations): 1. 2024
EACTS/EACTAIC Guidelines on patient blood management in adult cardiac surgery
in collaboration with EBCP (2024) Casselman FPA, Lance MD, Ahmed A, Ascari A,
Blanco-Morillo J, Bolliger
D, et al. European Journal of Cardio-Thoracic Surgery. 2024:ezae352. 9 Systematic Reviews:
ii) Desborough M, Sandu
R, Brunskill SJ, Doree C, Trivella M, Montedori A, et al. Fresh frozen plasma for
cardiovascular surgery. The Cochrane Database of Systematic Reviews.
2015;7:CD007614. PubMed ID: 26171897. iii) Desborough MJ, Oakland K, Brierley C,
Bennett S, Doree C, Trivella M, et al. Desmopressin use for minimising
perioperative blood transfusion. The Cochrane Database of Systematic
Reviews. 2017;7:CD001884. PubMed
ID: 28691229. iv) Desborough MJ, Oakland KA, Landoni G, Crivellari M, Doree
C, Estcourt LJ, et al. Desmopressin for treatment of platelet dysfunction and
reversal of antiplatelet agents: a systematic review and meta-analysis of
randomized controlled trials. Journal of Thrombosis and Haemostasis
: JTH. 2017;15(2):263-72. PubMed ID: 27893176. v) Estcourt LJ, Malouf R, Doree C, Trivella
M, Hopewell S, Birchall J. Prophylactic platelet transfusions prior to
surgery for people with a low platelet count. The Cochrane Database of
Systematic Reviews. 2018;9:CD012779.
PubMed ID: 30221749. vi) Lloyd TD, Geneen LJ, Bernhardt K, McClune W, Fernquest SJ, Brown
T, et al. Cell salvage for minimising perioperative allogeneic blood
transfusion in adults undergoing elective surgery. The Cochrane Database
of Systematic Reviews. 2023;9:CD001888.
PubMed ID: 37681564. vii) Simpson E, Lin Y, Stanworth S, Birchall
J, Doree C, Hyde C. Recombinant factor VIIa for the
prevention and treatment of bleeding in patients without haemophilia. The
Cochrane Database of Systematic Reviews. 2012;3:CD005011. PubMed ID: 22419303. viii) Stanworth SJ, Brunskill SJ, Hyde CJ,
McClelland DB, Murphy MF. Is fresh frozen plasma clinically effective? A
systematic review of randomized controlled trials. British Journal of
Haematology. 2004;126(1):139-52.
PubMed ID: 15198745. ix) Yang L, Stanworth S, Hopewell S, Doree
C, Murphy M. Is fresh-frozen plasma clinically effective? An update of a
systematic review of randomized controlled trials. Transfusion.
2012;52(8):1673-86; quiz PubMed ID: 22257164. 2. Strategies
to prevent blood loss and reduce transfusion in emergency general surgery,
WSES-AAST consensus paper (2024) Coccolini
F, Shander A, Ceresoli M,
Moore E, Tian B, Parini D, et al. World journal
of emergency surgery : WJES. 2024;19(1):26. 4 Systematic Reviews: ii) Desborough MJ, Oakland KA, Landoni G, Crivellari M, Doree
C, Estcourt LJ, et al. Desmopressin for treatment of platelet dysfunction and
reversal of antiplatelet agents: a systematic review and meta-analysis of
randomized controlled trials. Journal of Thrombosis and Haemostasis
: JTH. 2017;15(2):263-72.
PubMed ID: 27893176. iii) Fabes J, Brunskill SJ, Curry N, Doree
C, Stanworth SJ. Pro-coagulant haemostatic factors for the prevention and
treatment of bleeding in people without haemophilia. The Cochrane Database
of Systematic Reviews. 2018;12:CD010649.
PubMed ID: 30582172. iv) Simpson E, Lin Y, Stanworth S, Birchall
J, Doree C, Hyde C. Recombinant factor VIIa for the
prevention and treatment of bleeding in patients without haemophilia. The
Cochrane Database of Systematic Reviews. 2012;3:CD005011. PubMed ID: 22419303. 3. Red
Blood Cell Transfusion: 2023 AABB International Guidelines (2023) Carson JL, Stanworth SJ, Guyatt G, Valentine
S, Dennis J, Bakhtary S, et al. Jama.
2023;330(19):1892-902. 3 Systematic Reviews: iii) Stanworth SJ, New HV, Apelseth TO,
Brunskill S, Cardigan R, Doree C, et al. Effects of the COVID-19 pandemic on
supply and use of blood for transfusion. The Lancet Haematology.
2020;7(10):e756-e64.
PubMed ID: 32628911. 4. Patient
blood management guideline for adults with critical bleeding (2024) Australia NBA. 2024. 3 Systematic Reviews: i)
Curry N, Hopewell S, Dorée C, Hyde C, Brohi K,
Stanworth S. The acute management of trauma hemorrhage:
a systematic review of randomized controlled trials. Critical Care
(London, England). 2011;15(2):R92. PubMed ID: 21392371. iii) Simpson E, Lin Y, Stanworth S, Birchall
J, Doree C, Hyde C. Recombinant factor VIIa for the
prevention and treatment of bleeding in patients without haemophilia. The
Cochrane Database of Systematic Reviews. 2012;3:CD005011. PubMed ID: 22419303. 5. Perioperative
thrombocytopenia: review of current recommendations and implementation in
clinical practice (2023) Ploshchenko
YO, Novikov SP, Gavrish KV, Kusch VM, Karas RK. Emergency
Medicine (Ukraine). 2023;19(4):274-86. 3 Systematic Reviews:
iii) Estcourt LJ, Malouf R, Hopewell S,
Doree C, Van Veen J. Use of platelet transfusions prior to lumbar punctures
or epidural anaesthesia for the prevention of complications in people with
thrombocytopenia. The Cochrane Database of Systematic Reviews.
2018;4:CD011980. PubMed ID: 29709077. 6. Patient
blood management in major digestive surgery Recommendations from the Italian multisociety (ACOI, SIAARTI, SIdEM,
and SIMTI) modified Delphi consensus conference (2024) Catarci
M, Tritapepe L, Rondinelli
MB, Beverina I, Agostini V, Buscemi F, et al. Giornale di Chirurgia.
2024;44(1):E41. 3 Systematic Reviews: iii) Shah AA, Donovan K, Seeley C, Dickson
EA, Palmer AJR, Doree C, et al. Risk of Infection Associated With Administration of Intravenous Iron: A Systematic
Review and Meta-analysis. Jama Network Open. 2021;4(11):e2133935. PubMed
ID: 34767026. 7. Perioperative
Patient Blood Management (excluding obstetrics): Guidelines from the French
National Authority for Health (2024) Theissen
A, Folléa G, Garban F, Carlier M, Pontone S, Lassale B, et al. Anaesthesia Critical Care and Pain
Medicine. 2024;43(5 C7 - 101404). 3 Systematic Reviews: i)
Brunskill SJ, Millette SL, Shokoohi
A, Pulford EC, Doree C, Murphy MF, et al. Red blood
cell transfusion for people undergoing hip fracture surgery. The Cochrane
Database of Systematic Reviews. 2015;4:CD009699. PubMed ID: 25897628. iii) Docherty AB, O'Donnell R, Brunskill S,
Trivella M, Doree C, Holst L, et al. Effect of restrictive versus liberal
transfusion strategies on outcomes in patients with cardiovascular disease in
a non-cardiac surgery setting: systematic review and meta-analysis. BMJ
(Clinical research ed). 2016;352:i1351. PubMed ID: 27026510. 8. Guidelines
for the diagnosis and management of adult aplastic anaemia: A British Society
for Haematology Guideline (2024) Kulasekararaj
A, Cavenagh J, Dokal I, Foukaneli T, Gandhi S, Garg M, et al. British Journal
of Haematology. 2024;204(3):784-804. 2 Systematic Reviews: i)
Carson JL, Stanworth SJ, Alexander JH, Roubinian N,
Fergusson DA, Triulzi DJ, et al. Clinical trials
evaluating red blood cell transfusion thresholds: An updated systematic
review and with additional focus on patients with cardiovascular disease. American
Heart Journal. 2018;200:96-101. PubMed ID: 29898855. 9. Consensus
of the Brazilian association of hematology,
hemotherapy and cellular therapy on patient blood management: Anemia
tolerance (2024) De Santis GC,
Costa L, Brunetta DM, Magnus MM, Benites BD, Rodrigues RDR, et al. Hematology,
Transfusion and Cell Therapy. 2024;46:S67-S71. 2 Systematic Reviews: i)
Carson JL, Stanworth SJ, Roubinian N, Fergusson DA,
Triulzi D, Doree C, et al. Transfusion thresholds
and other strategies for guiding allogeneic red blood cell transfusion. The
Cochrane Database of Systematic Reviews. 2016;10:CD002042. PubMed ID: 27731885. ii) Docherty AB, O'Donnell R, Brunskill S,
Trivella M, Doree C, Holst L, et al. Effect of restrictive versus liberal
transfusion strategies on outcomes in patients with cardiovascular disease in
a non-cardiac surgery setting: systematic review and meta-analysis. BMJ
(Clinical research ed). 2016;352:i1351. PubMed ID: 27026510. 10. Guidelines
for the Administration of Blood Products (2024) ANZSBT.
2024. 2 Systematic Reviews:
11. Evidence-Based
Neonatal Transfusion Guidelines (2023) Ohls
RK. Principles of Neonatology. 2023:380-6. 1 Systematic Review: Venkatesh V, Khan R, Curley A, Hopewell S,
Doree C, Stanworth S. The safety and efficacy of red cell transfusions in
neonates: a systematic review of randomized controlled trials. British
Journal of Haematology. 2012;158(3):370-85. PubMed ID: 22639894. 12. Methodologic
Quality and Pharmacotherapy Recommendations for Patient Blood Management
Guidelines for Cardiac Surgery on Cardiopulmonary Bypass (2024) Huang X, Du P, Jia H, Wang A, Hua Y, Liu X,
et al. Journal of cardiothoracic and vascular anesthesia.
2024;38(7):1569-76. 1 Systematic Review: Simpson E, Lin Y, Stanworth S, Birchall J,
Doree C, Hyde C. Recombinant factor VIIa for the
prevention and treatment of bleeding in patients without haemophilia. The
Cochrane Database of Systematic Reviews. 2012;3:CD005011. PubMed ID: 22419303. 13. Management
of peri-surgical anemia in elective surgery. Conclusions and recommendations
according to Delphi-UCLA methodology (2024) Moral V, Abad Motos
A, Jericó C, Antelo Caamaño ML, Ripollés Melchor J,
Bisbe Vives E, et al. Revista
Espanola de Anestesiologia y Reanimacion.
2024;71(6):454-65. 1 Systematic Review: Shah AA, Donovan K, Seeley C, Dickson EA,
Palmer AJR, Doree C, et al. Risk of Infection Associated With
Administration of Intravenous Iron: A Systematic Review and Meta-analysis. Jama
Network Open. 2021;4(11):e2133935. PubMed ID: 34767026. 14. ESPEN
practical short micronutrient guideline (2024) Berger MM, Shenkin
A, Dizdar OS, Amrein K, Augsburger
M, Biesalski HK, et al. Clinical Nutrition.
2024;43(3):825-57. 1 Systematic Review: Shah AA, Donovan K, Seeley C, Dickson EA,
Palmer AJR, Doree C, et al. Risk of Infection Associated With
Administration of Intravenous Iron: A Systematic Review and Meta-analysis. Jama
Network Open. 2021;4(11):e2133935. PubMed ID: 34767026. 15. Federation
of Obstetric and Gynecological Societies of India
Consensus Recommendations for the Management of Postpartum Anemia with
Specific Reference to Usage of Ferric Carboxymaltose
(2024) Sekaran SK, Mukherjee B, Sharma JB, Wagh G, Bapat K, Wani R, et al. Journal of South Asian
Federation of Obstetrics and Gynaecology. 2024;16(S1):S43-S9. 1 Systematic Review: Parker JA, Barroso F, Stanworth SJ, Spiby H, Hopewell S, Doree CJ, et al. Gaps in the
evidence for prevention and treatment of maternal anaemia: a review of
systematic reviews. BMC pregnancy and childbirth. 2012;12:56. PubMed ID: 22727258. 16. AASLD
Practice Guidance on risk stratification and management of portal
hypertension and varices in cirrhosis (2024) Kaplan DE, Ripoll C, Thiele M, Fortune BE, Simonetto DA, Garcia-Tsao G, et al. Hepatology.
2024;79(5):1180-211. 1 Systematic Review: Odutayo
A, Desborough MJ, Trivella M, Stanley AJ, Dorée C, Collins GS, et al.
Restrictive versus liberal blood transfusion for gastrointestinal bleeding: a
systematic review and meta-analysis of randomised controlled trials. The
Lancet Gastroenterology & Hepatology. 2017;2(5):354-60. PubMed ID: 28397699. 17. Guidelines
for the diagnosis and treatment of acute non-variceal upper gastrointestinal
bleeding in Chinese children (2024) Subspecialty Group of Gastroenterology, the
Society of Pediatrics, Chinese Medical Association;
National Clinical Research Center for Child Health
Children′s Digestive Disease Diagnosis and Treatment Collaborative
Innovation Alliance; Editorial Board, Chinese Journal of Pediatrics.
Chinese Journal of Pediatrics.
2024;62(7):596-606.parker 1 Systematic Review: Odutayo
A, Desborough MJ, Trivella M, Stanley AJ, Dorée C, Collins GS, et al.
Restrictive versus liberal blood transfusion for gastrointestinal bleeding: a
systematic review and meta-analysis of randomised controlled trials. The
Lancet Gastroenterology & Hepatology. 2017;2(5):354-60. PubMed ID: 28397699. 18. Toward a
more patient-centered drug development process in
clinical trials for patients with myelodysplastic syndromes/neoplasms (MDS):
Practical considerations from the International Consortium for MDS (icMDS) (2024) Efficace
F, Buckstein R, Abel GA, Giesinger JM, Fenaux P, Bewersdorf JP, et al. HemaSphere.
2024;8(5):e69. 1 Systematic Review: Mo A, Poynton M, Wood E, Shortt J, Brunskill
SJ, Doree C, et al. Do anemia treatments improve quality of life and physical
function in patients with myelodysplastic syndromes (MDS)? A systematic
review. Blood Reviews. 2023;61:101114. PubMed ID: 37479599. 19. Perioperative
management of patients with hemostatic system
disorders. Methodological recommendations of the All-Russian public
organization “Federation of Anesthesiologists and Reanimatologists” and the National Association of
Specialists in Thrombosis, Clinical Hemostasiology
and Hemorheology (2024) Zabolotskikh
IB, Sinkov SV, Bulanov AY, Vorobyova NA, Eremenko
AA, Kuzovlev AN, et al. Annals of Critical Care.
2024;2024(1):7-46. 1 Systematic Review: McQuilten
ZK, Crighton G, Engelbrecht S, Gotmaker
R, Brunskill SJ, Murphy MF, et al. Transfusion interventions in critical
bleeding requiring massive transfusion: a systematic review. Transfusion
Medicine Reviews. 2015;29(2):127-37.
PubMed ID: 25716645. 20. Consensus
of the Brazilian association of hematology,
hemotherapy and cellular therapy on patient blood management: Acute normovolemic hemodilution and
intraoperative autotransfusion (2024) Perini FV, Montano-Pedroso JC, Oliveira LC,
Donizetti E, Rodrigues RDR, Rizzo SRCP, et al. Hematology,
Transfusion and Cell Therapy. 2024;46:S48-S52. 1 Systematic Review: Lloyd TD, Geneen LJ, Bernhardt K, McClune W, Fernquest SJ, Brown
T, et al. Cell salvage for minimising perioperative allogeneic blood
transfusion in adults undergoing elective surgery. The Cochrane Database
of Systematic Reviews. 2023;9:CD001888.
PubMed ID: 37681564. 21. Albumin:
a comprehensive review and practical guideline for clinical use (2024) Abedi F, Zarei B, Elyasi S. European Journal of Clinical Pharmacology.
2024;80(8):1151-69. 1 Systematic Review: Kohli R, Geneen LJ, Brunskill SJ, Doree C,
Estcourt L, Chee SEJ, et al. Assessing efficacy and safety of replacement
fluids in therapeutic plasma exchange: A systematic scoping review of outcome
measures used. Journal of Clinical Apheresis. 2022; 37(5):438-448. PubMed ID: 35726507. 22. A
British Society for Haematology guideline on the assessment and management of
bleeding risk prior to invasive procedures (2024) Lester W, Bent C, Alikhan R, Roberts L,
Gordon-Walker T, Trenfield S, et al. British
Journal of Haematology. 2024;204(5):1697-713. 1 Systematic Review: Huber J, Stanworth SJ, Doree C, Fortin PM,
Trivella M, Brunskill SJ, et al. Prophylactic plasma transfusion for patients
without inherited bleeding disorders or anticoagulant use undergoing non-cardiac
surgery or invasive procedures. The Cochrane Database of Systematic
Reviews. 2019;11:CD012745. PubMed
ID: 31778223. 23. Consensus
of the Brazilian association of hematology,
hemotherapy and cellular therapy on patient blood management: Assessment and
management of postoperative anemia (2024) Benites
BD, Magnus MM, Costa L, Brunetta DM, Rodriges RDR, Alves SDOC, et al. Hematology,
Transfusion and Cell Therapy. 2024;46:S72-S6. 1 Systematic Review: Geneen LJ, Kimber C, Doree C, Stanworth S,
Shah A. Efficacy and Safety of Intravenous Iron Therapy for Treating Anaemia
in Critically ill Adults: A Rapid Systematic Review with Meta-Analysis. Transfusion
Medicine Reviews. 2021 PubMed ID: 35031197. 24. Blood
Donation in the EU: Exploring Behavioural Insights for Innovative
Interventions. A literature review and an overview of the blood donation
landscape in the EU (2023) Fisher SA, Allen D, Dorée C, Naylor J, Di Angelantonio E, Roberts DJ. Interventions to reduce
vasovagal reactions in blood donors: a systematic review and meta-analysis. Transfusion
Medicine (Oxford, England). 2016;26(1):15-33. PubMed ID: 27061617. 25. [S1-Guideline:
Non-suppurative CNS infections of the brain and spinal cord in childhood and
adolescence] (2024) Häusler
M. Gesellschaft für Neuropädiatrie
[Society for Pediatric Neurology]. 2024. 1 Systematic Review: Estcourt LJ, Desborough MJ, Doree C,
Hopewell S, Stanworth SJ. Plasma transfusions prior to lumbar punctures and
epidural catheters for people with abnormal coagulation. The Cochrane
Database of Systematic Reviews. 2017;9:CD012497. PubMed ID: 28945930. 26. Management
of chemotherapy-induced thrombocytopenia: guidance from the ISTH Subcommittee
on Hemostasis and Malignancy (2024) Soff
G, Leader A, Al-Samkari H, Falanga
A, Maraveyas A, Sanfilippo K, et al. Journal of
Thrombosis and Haemostasis. 2024;22(1):53-60. 1 Systematic Review: Estcourt LJ, Stanworth SJ, Doree C, Hopewell
S, Trivella M, Murphy MF. Comparison of different platelet count thresholds
to guide administration of prophylactic platelet transfusion for preventing
bleeding in people with haematological disorders after myelosuppressive
chemotherapy or stem cell transplantation. The Cochrane Database of
Systematic Reviews. 2015;11:CD010983.
PubMed ID: 26576687. 27. Standardization
of definition and management for bleeding disorder of unknown cause:
communication from the SSC of the ISTH (2024) Baker RI, Choi P, Curry N, Gebhart J, Gomez K, Henskens Y,
et al. Journal of Thrombosis and Haemostasis. 2024;22(7):2059-70. 1 Systematic Review: Desborough MJR, Obaji
S, Lowe GC, Doree C, Thomas W. Management of surgery, menorrhagia and
child-birth for patients with unclassified bleeding disorders: a systematic
review of cohort studies. Blood Coagulation & Fibrinolysis
: An International Journal in Haemostasis and Thrombosis.
2021;32(6):366-72. PubMed ID:
33973892. 28. Diagnosis
and management of abnormal uterine bleeding in adolescence: An expert
Consensus Statement of SIGO (Italian Society of Gynecology
and Obstetrics) and SISET (Italian Society for the Study of Hemostasis and Thrombosis) (2024) Santi RM, Fulghesu
A, Zanon E, De Candia E, Grandone
E, Di Renzo G, et al. Bleeding, Thrombosis and Vascular Biology.
2024;3(1):Consensus Papers. 1 Systematic Review: Desborough MJ, Oakland KA, Landoni G, Crivellari M, Doree C,
Estcourt LJ, et al. Desmopressin for treatment of platelet dysfunction and
reversal of antiplatelet agents: a systematic review and meta-analysis of
randomized controlled trials. Journal of Thrombosis and Haemostasis
: JTH. 2017;15(2):263-72.
PubMed ID: 27893176. 29. ANMCO/SIMEU
consensus document on the use of reversal agents for antithrombotic therapies
in patients with ongoing bleeding or at high risk of haemorrhagic events
(2024) De Luca L, Pugliese FR, Susi B, Navazio A, Corda M, Fabbri A,
et al. European Heart Journal, Supplement. 2024;26(Supplement 2):ii211-ii20. 2 Systematic Reviews: i)
Desborough MJ, Oakland K, Brierley C, Bennett S, Doree C, Trivella M, et al.
Desmopressin use for minimising perioperative blood transfusion. The
Cochrane Database of Systematic Reviews. 2017;7:CD001884. PubMed ID: 28691229. ii) Desborough MJ, Oakland KA, Landoni G, Crivellari M, Doree
C, Estcourt LJ, et al. Desmopressin for treatment of platelet dysfunction and
reversal of antiplatelet agents: a systematic review and meta-analysis of
randomized controlled trials. Journal of Thrombosis and Haemostasis
: JTH. 2017;15(2):263-72.
PubMed ID: 27893176. 30. S2k
guideline: Prehospital treatment guidelines for disaster medicine (2024) Rohde A, Francis R, Gräsner
JT, Heller AR, Latasch L, Franke A, et al. Anasthesiologie und Intensivmedizin.
2024;65(1):S11-S38. 1 Systematic Review: Curry N, Hopewell S, Dorée C, Hyde C, Brohi K, Stanworth S. The acute management of trauma hemorrhage: a systematic review of randomized controlled
trials. Critical Care (London, England). 2011;15(2):R92. PubMed ID: 21392371. 31. Chirurgie bij kwetsbare ouderen [Surgery in
vulnerable elderly people] (2024) Nederlandse
Vereniging voor Klinische Geriatrie [Dutch
Association of Clinical Geriatrics] 1 Systematic Review: Brunskill SJ, Millette
SL, Shokoohi A, Pulford EC, Doree C, Murphy MF, et
al. Red blood cell transfusion for people undergoing
hip fracture surgery. The Cochrane Database of Systematic Reviews.
2015;4:CD009699. PubMed ID: 25897628. 32. Chinese
expert consensus on autologous stem cell transplantation for the treatment of
heart failure (2022) (2023) 1 Systematic Review: Fisher SA, Doree C, Mathur A, Taggart DP,
Martin-Rendon E. Cochrane corner: Stem cell therapy for chronic ischaemic
heart disease and congestive heart failure. Heart.
2018;104(1):8-10. PubMed ID: 28607164. |
|
Research Tools & Methods |
NIHR Cochrane programme grant [2]. We have used a form of analysis, network meta-analysis (NMA), for the systematic reviews being undertaken through our NIHR Cochrane programme grant. We continue to use Covidence for all our screening activities and had used Covidence to undertake data extraction for the Cochrane reviews in our NIHR Cochrane Programme Grant and our smaller systematic reviews. However, having had significant issues with extracting data using this software, we are currently not using Covidence for data extraction. We
have had interesting internal conversations about what current AI tools being
developed for evidence synthesis could add to our activity and received a demonstration
of Laser AI (October 2024). We are aware of the need to stay abreast of all
developments in this field but believe that the limitations of their use at
the current time do not outweigh the advantages those developing these
products seek to explain. For example, Laser AI does not support double data
extraction and its products to support screening are based on one screeners
decision making – hence, there is the assumption that the decisions of the
single screener are always correct, something we know not to be the case. |
|
Research Databases & Models |
See section below: Software & Technical Products |
|
Intellectual Property & Licensing |
Conversations
with NHSBT Procurement over the last few years have highlighted that aspects of our two Electronic Libraries should be
registered as intellectual property, most specifically the database
structure. However, the current structure of the database was developed by Evidentia Publishing and they do not think it is
appropriate to apply for intellectual property for the database structure. There
was interest within NHSBT in bringing the development and hosting of both
electronic libraries in-house and, should that happen, we could explore
registering intellectual property rights for the new structure of the
electronic libraries. However, conversations during 2023 have highlighted
that whilst there is interest from a database architecture and design perspective,
there is no interest from decision-makers within NHSBT responsible for
investment in resources and therefore we will not be bringing the development
and hosting of both electronic libraries in-house. |
|
Medical Products, Interventions and Clinical Trials |
CLINICAL TRIALS that have developed from one of our systematic reviews in the past 12 months: · REVIEW: Desmopressin for minimising red cell transfusion. [2017] and Desmopressin for treatment of platelet dysfunction and reversal of antiplatelet agents: a systematic review and meta-analysis of randomized controlled trials [2017]. CLINICAL TRIAL: DASH-2 trial. 1000 patient trial of desmopressin versus placebo for intracerebral haemorrhage. Funding from NIHR Research for Patient Benefit (RfPB). NIHR RfPB PB-PG-0816-20011. ·
REVIEW: Fresh frozen plasma for
cardiovascular surgery [2015] and Pro-coagulant haemostatic factors
for the prevention and treatment of bleeding in people
without haemophilia [2018], CLINICAL TRIAL:
PROPHESY -2
trial is assessing whether prothrombin complex concentrate (PCC) is superior
to fresh frozen plasma (FFP) in the treatment of adult patients who are
actively bleeding within 24 hours of their cardiac surgery.
· REVIEW: Efficacy and Safety of Intravenous Iron Therapy for Treating Anaemia in Critically ill Adults: A Rapid Systematic Review with Meta-Analysis [2022]. 1 application to NIHR EME. CLINICAL TRIAL: INTACT-2. Received NIHR funding through to 2027. Co-applicants – Simon Stanworth, Akshay Shah ONGOING CLINICAL TRIALS that have been developed from one of our systematic reviews: · REVIEW: The Difference in Potential Harms between Whole Blood and Component Blood Transfusion in major Bleeding: A Rapid Systematic Review and Meta-Analysis of RCTs [2022]. CLINICAL TRIAL: SWIFT: study of Whole Blood in Frontline Trauma. A multi-centre randomised controlled trial of the clinical effectiveness and cost-effectiveness of pre-hospital whole blood administration versus standard care for traumatic haemorrhage. Trial status: Recruitment complete and close: October 2024. ·
REVIEW: Gaps in
the evidence for prevention and treatment of maternal anaemia: a review of
systematic reviews [2012]: ·
REVIEW Granulocytes for preventing infection
[2016]: ·
REVIEW Granulocytes for treating infection
[2016]: ·
REVIEW: Prophylactic platelet transfusions in
critically ill patients [2018]. · REVIEWS: Red blood cell transfusion
in hip fracture surgery [2016] and Red cell transfusion
threshold review [2020].
GRANT APPLICATIONS made in the last 12 months that have developed from one of our systematic reviews: ·
REVIEW: Desborough
MJ, Oakland K, Brierley C, Bennett S, Doree C, Trivella M,
Hopewell S, Stanworth SJ. Desmopressin for minimising red cell transfusion. Cochrane
Database Syst Rev 2017; 7(7): CD001884
and Desborough MJ, Oakland KA, Landoni G, Crivellari, Doree C, Estcourt LJ, Stanworth SJ.
Desmopressin for treatment of platelet dysfunction and reversal of
antiplatelet agents: a systematic review and meta-analysis of randomized
controlled trials. J Thromb Haemost
2017; 15(2): 263-72. |
|
Artistic & Creative Products |
Nothing
to report. |
|
Transfusion Evidence Library (www.transfusionevidencelibrary.com). As of October 2024, the library contains 15,988 records. Of those 10,823 are RCTs, 5,007 are Systematic Reviews and 100 are Economic Studies. We now also include RCT and systematic review protocols on the Library (34 and 7 respectively) Annual maintenance bill= £ 25,000. The
Transfusion Evidence Library has the facility to highlight Featured Articles,
and this year this functionality was used to highlight the top articles from
the most recent Evidence Alerts and Round-Ups. Four Transfusion Evidence Round-Ups were emailed for the following awareness days: The Best of the Transfusion Evidence Library (5th December 2023), World Kidney Day (14th March 2024), International Children’s Day (3rd June 2024), World Trauma Day (17th October 2024). Transfusion Evidence
Library usage (taken from Google Analytics data) · Between October 2023 and
September 2024, the Transfusion Evidence Library (TEL) was visited from 121
countries; the TEL had 12,335 users, which is an increase in 11% in the
number of users from the same period last year. · Between October 2023 and
September 2024, TEL users by country were: 35% from USA, 13% from Australia,
9.6% from UK, 4.2% from Canada and 3.7% from Germany. Like the previous year,
the USA was the country from where most visits originated. · Most users (80%) came to
TEL directly or by typing the URL. 9.8% arrived via links sent through
emails, 6.3% arrived via organic search, and 3.1% arrived from social media
(X, LinkedIn or Facebook) Transfusion Evidence Alert We have 8,295 subscribers to the Transfusion Evidence Alert and Transfusion Evidence Round-Up. Transfusion Evidence Library on Twitter (now X) (@TransfusionLib). On 18th October 2024, Transfusion Evidence Library had 3,456 followers [a slight rise from the previous year]. Tweets are posted about monthly email alerts and their contents, relevant awareness days, news items that contain content relevant to the Transfusion Evidence Library, as well as retweeting tweets from the SRI and SCE Twitter/X streams as relevant. We have also publicised the Transfusion Evidence Round-Ups through the TEL Twitter/X account, and through the TEL Facebook page. We are continuing to monitor the situation with Twitter/X and have explored other options for social media. We have set up Mastodon accounts for both libraries and are actively posting on LinkedIn. We are monitoring Bluesky, Threads and Mastodon as potential places to migrate our Twitter presence, but all of the potential options have limitations. A
link to the Transfusion Evidence Library website link can be found on 515
sites, including the following: ·
British Blood Transfusion Society: · NHSBT Library, Evidence Search section. · Canadian Society for Transfusion Medicine: · Institute of Scientific Information, Charles University, First Faculty of Medicine and General University Hospital in Prague · Wikipedia article [External Links]: · NHS Leeds Libraries: · NHS Velindre University: · Pavol Jozef Safarik University, Kosice, Slovak Republic · National Medical Library, Prague · LinkedIn: · mentioned on the ISBT website. Other dissemination: · A report with the monthly content uploaded in TEL is emailed to the editor of Transfusion Medicine Reviews. · A report is emailed
every six months with the content uploaded in TEL to the Royal College of
Pathologists. · The link to the top
records featured is included in the NHSBT R&D monthly newsletter. · The NHSBT librarian
posts in Viva Engage about both alerts (SCE and TEL) every month. Transfusion
Evidence Library has been cited in the following 17 publications since
October 2023:
Apelseth
TO, Raza S, Callum J, Ipe T, Blackwood B, Akhtar A, et al. Transfusion.
64(6):1116-31. 2. Safety and efficacy of
tranexamic acid in major non-cardiac vascular surgery: a systematic review
and meta-analysis (2024) Atha
K, Corrigan, L, Bera K, Shah A. Journal of the Vascular Societies of Great
Britain and Ireland. 2024;3 (4):194-202. 3. Cold versus room temperature
storage of platelets for haemorrhage control (2023). 4. Universal irradiation of
platelets: Does irradiation affect the quality, effectiveness, and safety of
platelets for transfusion? (2024) 5. Balancing Donor Health and
Plasma Collection: A Systematic Review of the Impact of Plasmapheresis
Frequency (2024) D'Aes T, van den Hurk
K, Schroyens N, Mikkelsen S, Severijns
P, De Buck E, et al. Transfusion Medicine Reviews. 2024:150851. 6. Does peri-operative red
blood cell transfusion increase the risk of cancer recurrence in patients
undergoing curative surgery? Umbrella review of observational research and
summary of randomised controlled trial evidence (2024) Etheridge
JS, P.; Walsh, T.; Shah, A.; Stanworth, S.; Harrison, E. Anaesthesia.
2024;79(S1):7-88. 7. Pharmacological
interventions for the prevention of bleeding in people undergoing elective
hip or knee surgery: a systematic review and network meta-analysis (2024) Gibbs
VN, Champaneria R, Sandercock J, Welton NJ, Geneen LJ, Brunskill SJ, et al. The
Cochrane Database of Systematic Reviews. 2024;1:CD013295. 8. A feasibility study
examining the potential of introducing a whole blood component for the management
of traumatic major haemorrhage (2023) 9. Defining ultra-massive
transfusion through a systematic review (2024) Meyer
CH, Bailey NM, Leslie SL, Thrasher K, Grady Z, Sanders M, et al. The American
Journal of Surgery 2024. p. 192-8. 10. Plasma transfusion to prevent
intraventricular haemorrhage in very preterm infants (2023) Neary
E, Murphy CA, Ní Áinle F,
El-Khuffash A, Cotter M, Kirkham C, et al. Cochrane
Database of Systematic Reviews (Protocol). 2023(5). 11. Quality evaluation and content
analysis of guidelines for time limit management in transfusion nursing (2024) NI
L-fL, Lin; SHEN, Chun-hua;
QIAO, Yao; ZHOU, Liang; ZHU, Qiang; GONG, Wei-juan. Journal of Nursing. 2024;31(7):51-6. 12. Restrictive versus liberal red
blood cell transfusion strategies for people with haematological malignancies
treated with intensive chemotherapy or radiotherapy, or both, with or without
haematopoietic stem cell support (2024) Radford
M, Estcourt LJ, Sirotich E, Pitre T, Britto J, Watson M, et al. Cochrane
Database of Systematic Reviews. 2024(5):CD011305. 13. Does early transfusion of
cold-stored whole blood reduce the need for component therapy in civilian
trauma patients? A systematic review (2024) Risha M, Alotaibi A, Smith S, Priestap F, Iansavitchene A,
Laverty C, et al. The Journal of Trauma and Acute Care Surgery. 2024;97(5):p 822-829. 14. Assessing the one-month
mortality impact of civilian-setting prehospital transfusion: A systematic review
and meta-analysis (2024) Schoenfeld
DW, Rosen CL, Harris T, Thomas SH. Academic Emergency Medicine.
2024;31(6):590-8. 15. Preoperative bleeding risk
assessment in cardiac surgery patients (2024) Zyuzin VS. Surgical Practice. 2024;2:80-96. 16. Desmopressin to reduce
periprocedural bleeding and transfusion: a systematic review and
meta-analysis (2024) Wang
C, Lebedeva V, Yang J, Anih J, Park LJ, Paczkowski
F, et al. Perioperative Medicine. 2024;13(1):5. 17. Modern strategy for the use of
allogeneic blood in cardiac surgery (2024) Zyuzin
V.S.; Shneider, Y.A.. Russian Journal
of Thoracic and Cardiovascular Surgery. 2024;66(3):282-90. Stem
Cell Evidence www.stemcellevidence.com As of September
2023, the library contains 14,384 records (a rise of ~1400), including 579
RCTs, 708 systematic reviews, and 310 guidelines. Since November 2022, Stem
Cell Evidence has the facility to highlight Featured Articles, using the
functionality developed to display COVID-19 records.
Peck
RC, Knapp-Wilson A, Burley K, Doree C, Griffin J, Mumford AD, et al. Scoping
review of factors associated with stem cell mobilisation and collection in
allogeneic stem cell donors. Transplantation and Cellular Therapy.
2024;30(9):844-863. PubMed ID: 38851322 Stem Cell Evidence usage (taken from Google Analytics data). In the past year (from October 2023 to September 2024), Stem Cell Evidence has had 12,000 page-views from 3,012 individual users, from more than 80 countries. ·
Stem Cell Evidence users by country were: 25% from USA, 19% from Singapore,
12% from UK, 10% from Australia, 2.5% from India, 2.4% from Spain, 2.2% from
China, 2.2% from the Netherlands, 2% from Brazil. ·
Most users (79%) came to Stem Cell Evidence directly, either by typing the
URL or using a bookmark, 12% of users arrived by searching the internet, and
4% of users arrived by social media. Stem Cell Evidence Alert. We have 1,331 subscribers to the Stem Cell Evidence Alert. Stem Cell Evidence on Twitter/X (@evidencestemc). On 18th October 2024 Stem Cell Evidence had 579 followers [a 6% rise from the previous year]. Tweets are posted about monthly email alerts and their contents, relevant awareness days, news items that contain content relevant to Stem Cell Evidence as well as retweeting tweets from the SRI and TEL Twitter/X streams as relevant. We continue to monitor the situation with Twitter/X and have set up a Mastodon account for the libraries. A
link to Stem Cell Evidence can be found on 60 websites, an increase from 33
in the previous year, including: · Hospital.blood.co.uk · Eurogct.org · Rcpath.org · Canterbury Christ Church
University We
have convened a Stem Cell Evidence Working Group of interested clinicians and
scientists to try to increase the reach and dissemination of Stem Cell
Evidence. We have explored potential improvements to the Library,
ways of disseminating the Library and ways of finding more support and
partnership opportunities within the Stem Cell community. As a result of the group’s recommendations,
we have taken the libraries to the EBMT conference April 2024 and provided
publicity materials to the BGSCT meeting in June 2024. We also implemented an “Older Adults”
patient type filter on the Library. We are still
struggling to break into Stem Cell networks to any great degree; however, we
are separately making contact with the ISBT Cellular Therapies Working Party,
through our networks forged via the Transfusion Evidence Round-Up. |
|
|
Awards and Recognition |
People · Mike Desborough, our new Assistant Clinical Director, was made an Associate Professor of Haematology, University of Oxford in May 2024 · Lise Estcourt, SRI Clinical Director, became NHSBTs new Medical Director of Transfusion in June 2024 · Mike Desborough was awarded researcher of the year 2024, from National Institute for Health and Care Research (NIHR) – British Society for Haematology (BSH) |
|
Use of Facilities & Resources |
Training Received: SRI team members have attended the following training activities since 1st November 2023: Susan Brunskill attended, · Cochrane ‘New guidance
on using the Risk of Bias In Non-randomised Studies
- of Interventions (ROBINS-I) tool’, October 2023 · Open House for Leaders:
April 2024, 4-week course on ‘Necessary Conversations’. · NHSBT Clinical Fellows Day, 23rd April 2024 · Open House for Leaders:
June 2024, 4-week course on Leading Change · ISBT Annual Conference,
24-26 June 2024 in Barcelona · Cochrane “Writing a
Cochrane abstract in the focused review format”, 4 September 2024 · BBTS Annual Conference,
16 – 19 September 2024 in Glasgow · Cochrane & Global
Evidence Summit’s update on AI in Guidelines & Evidence Synthesis, 26
September 2024 · Open House for Leaders:
October 2024, 4-week course on Resolving Challenging Relationships. Carolyn Doree · Webinar on
Modernized ClinicalTrials.gov – April 2024 · NHSBT Q-Pulse
SOP Document Control Training – April 2024 · Lunch and
Learn, NHSBT Image Library - August 2024 · Rachel
Johnson session on giving feedback - September 2024 ·
Webinar on “AI in Guidelines & Evidence Synthesis” - September
2024 Louise Geneen attended · webinar “Updated guidance on how to interpret and assess imprecision with GRADE methods”, 11 Jan 2024 ·
webinar “Evidence synthesis and certainty of evidence ratings in
rapid reviews, 25 Jan 2024 ·
webinar “Identifying who benefits most from treatments: estimating
interactions and subgroup effects in aggregate data meta-analysis”, 29 Jan 2024 ·
webinar “Conducting A Systematic Review with Laser AI”, 30 Jan 2024 ·
webinar “Introducing Cochrane’s Focused Review Format template: an
essential tool for authors”, 15 Feb 2024 · half day in-person course “R: a first look, University of Oxford, 6 February 2024 ·
webinar “Writing a Cochrane abstract in the focused review format”,
4 Sept 2024 ·
webinar “AI in Guidelines & Evidence Synthesis”, 26 Sept 2024 · Cochrane/Global Evidence Summit,
Prague, Sept 2024 Catherine Kimber attended, · R course -
February 2024 · Plasma for
medicine seminar - March 2024 · NHSBT change
control training - April 2024 · 8th International
Congress of the ISBT, Barcelona, Spain - June 2024 · Lunch and
Learn, NHSBT Image Library - August 2024 · Rachel
Johnson session on giving feedback - September 2024 · NHSBT
conference, Bristol UK - September 2024 · Statistics
and research seminar - October 2024 Alicia Plaza-Cajide attended, · How to fill
a good Creative Services brief and why is it important, (September 2024,
on-line), NHSBT. · Partnership
campaign with Disney: Deadpool & Wolverine (partnership insights and
marketing strategies), (July 2024, on-line), NHSBT. · Compelling
outreach with social media cards (March 2024, in person), IT Learning Centre,
University of Oxford. · Social
Media: Navigating your choices post Twitter (Feb 2024, on-line), IT Learning
Centre, University of Oxford. Rita Solanki attended: · TxEd Talk - The role of H&I in Patient Care with Dr Katy Latham, 21st November 2023 · Statistics and Clinical Research Seminar Series – Development of CUSUM Monitoring for Organ Retrieval Damage with Rachel Hogg, 30th November 2024 · Statistics and Clinical Research Seminar Series - What is a systematic review? Susan Brunskill, 26th March 2024 · Organ Donation Week webinar - 30 years of the NHS Organ Donor Register – Christine Cox, 24th September 2024 · Statistics and Clinical Research Seminar Series - Challenges extracting data from the literature with Josie Sandercock, 17th October 2024 |
|
Other Outputs & Knowledge
|
The information science
workload has remained constant this past year. In addition to the core search
activities for our reviews and the libraries, during 2023/24 Carolyn has also
given full information science support to the following external projects (with
some costs recovered for the SRI):
i.
BTRU and Economic Studies SR update search (Simon
Stanworth, January 2024)
ii.
BTRU Clinical Indicators for Transfusion SR update
search (Simon Stanworth, May 2024)
iii.
Jeff Carson’s Transfusion Thresholds SR (Cochrane)
update search (Simon Stanworth, October 2024).
iv.
Fresh Frozen Plasma overview SR update search
(Simon Stanworth, October 2024) |